Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection
AuthorMcAuley, J; Deng, Y-M; Gilbertson, B; Mackenzie-Kludas, C; Barr, I; Brown, L
Source TitleVirology Journal
PublisherBIOMED CENTRAL LTD
University of Melbourne Author/sGilbertson, Bradley; McAuley, Julie; Mackenzie-Kludas, Charley; Brown, Lorena; Barr, Ian
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsMcAuley, J., Deng, Y. -M., Gilbertson, B., Mackenzie-Kludas, C., Barr, I. & Brown, L. (2017). Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection. VIROLOGY JOURNAL, 14 (1), https://doi.org/10.1186/s12985-017-0827-0.
Access StatusOpen Access
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical "inflammatory" residues.
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