dc.contributor.author | Wiede, F | |
dc.contributor.author | Dudakov, JA | |
dc.contributor.author | Lu, K-H | |
dc.contributor.author | Dodd, GT | |
dc.contributor.author | Butt, T | |
dc.contributor.author | Godfrey, DI | |
dc.contributor.author | Strasser, A | |
dc.contributor.author | Boyd, RL | |
dc.contributor.author | Tiganis, T | |
dc.date.accessioned | 2020-12-21T01:59:49Z | |
dc.date.available | 2020-12-21T01:59:49Z | |
dc.date.issued | 2017-09-01 | |
dc.identifier | pii: jem.20161903 | |
dc.identifier.citation | Wiede, F., Dudakov, J. A., Lu, K. -H., Dodd, G. T., Butt, T., Godfrey, D. I., Strasser, A., Boyd, R. L. & Tiganis, T. (2017). PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification. JOURNAL OF EXPERIMENTAL MEDICINE, 214 (9), pp.2733-2758. https://doi.org/10.1084/jem.20161903. | |
dc.identifier.issn | 0022-1007 | |
dc.identifier.uri | http://hdl.handle.net/11343/256744 | |
dc.description.abstract | In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αβ TCR or γδ TCR T cells. | |
dc.language | English | |
dc.publisher | ROCKEFELLER UNIV PRESS | |
dc.title | PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification | |
dc.type | Journal Article | |
dc.identifier.doi | 10.1084/jem.20161903 | |
melbourne.affiliation.department | Microbiology and Immunology | |
melbourne.affiliation.department | Medical Biology (W.E.H.I.) | |
melbourne.affiliation.department | Sir Peter MacCallum Department of Oncology | |
melbourne.affiliation.department | Physiology | |
melbourne.source.title | Journal of Experimental Medicine | |
melbourne.source.volume | 214 | |
melbourne.source.issue | 9 | |
melbourne.source.pages | 2733-2758 | |
dc.rights.license | CC BY-NC-SA | |
melbourne.elementsid | 1229544 | |
melbourne.contributor.author | Tiganis, Tony | |
melbourne.contributor.author | Godfrey, Dale | |
melbourne.contributor.author | Strasser, Andreas | |
melbourne.contributor.author | Dodd, Garron | |
dc.identifier.eissn | 1540-9538 | |
melbourne.accessrights | Open Access | |