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dc.contributor.authorWiede, F
dc.contributor.authorDudakov, JA
dc.contributor.authorLu, K-H
dc.contributor.authorDodd, GT
dc.contributor.authorButt, T
dc.contributor.authorGodfrey, DI
dc.contributor.authorStrasser, A
dc.contributor.authorBoyd, RL
dc.contributor.authorTiganis, T
dc.date.accessioned2020-12-21T01:59:49Z
dc.date.available2020-12-21T01:59:49Z
dc.date.issued2017-09-01
dc.identifierpii: jem.20161903
dc.identifier.citationWiede, F., Dudakov, J. A., Lu, K. -H., Dodd, G. T., Butt, T., Godfrey, D. I., Strasser, A., Boyd, R. L. & Tiganis, T. (2017). PTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification. JOURNAL OF EXPERIMENTAL MEDICINE, 214 (9), pp.2733-2758. https://doi.org/10.1084/jem.20161903.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/256744
dc.description.abstractIn the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted αβ T cell receptor (TCR) T cells and non-MHC-restricted γδ TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into αβ TCR versus γδ TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate αβ TCR versus γδ TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into αβ TCR or γδ TCR T cells.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.titlePTPN2 regulates T cell lineage commitment and alpha beta versus gamma delta specification
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20161903
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentPhysiology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume214
melbourne.source.issue9
melbourne.source.pages2733-2758
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1229544
melbourne.contributor.authorTiganis, Tony
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorStrasser, Andreas
melbourne.contributor.authorDodd, Garron
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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