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    Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004-2011

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    Author
    Wang, Q; Wang, L; Fang, L; Wang, A; Jin, X; Wang, F; Wang, X; Qiao, Y; Sullivan, SG; Rutherford, S; ...
    Date
    2016-10-10
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Sullivan, Sheena
    Affiliation
    Doherty Institute
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Wang, Q., Wang, L., Fang, L., Wang, A., Jin, X., Wang, F., Wang, X., Qiao, Y., Sullivan, S. G., Rutherford, S. & Zhang, L. (2016). Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004-2011. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep34526.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256772
    DOI
    10.1038/srep34526
    Abstract
    This study investigates the improvement of the prevention of mother-to-child transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in China during 2004-2011. A clinic-based prospective study was conducted among HIV-positive pregnant women and their children in eight counties across China. Associated factors of mother-to-child transmission were analyzed using regression analysis. A total of 1,387 HIV+ pregnant women and 1,377 HIV-exposed infants were enrolled. The proportion of pregnant women who received HIV testing increased significantly from 45.1% to 98.9% during 2004-2011. Among whom, the proportion that received antiretroviral (ARV) prophylaxis increased from 61% to 96%, and the corresponding coverage in children increased from 85% to 97% during the same period. In contrast, single-dose nevirapine treatment during delivery declined substantially from 97.9% to 12.7%. Vertical transmission of HIV declined from 11.1% (95% confidence interval [CI]: 5.7-23.3%) in 2004 to 1.2% (95% CI: 0.1-5.8%) in 2011. Women who had a vaginal delivery (compared to emergency caesarian section (odds ratio [OR] = 0.46; 0.23-0.96)) and mothers on multi-ARVs (OR = 0.11; 0.04-0.29) were less likely to transmit HIV to their newborns. Increasing HIV screening enabled timely HIV care and prophylaxis to reduce vertical transmission of HIV. Early and consistent treatment with multi-ARVs during pregnancy is vital for PMTCT.

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