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dc.contributor.authorTurner, KM
dc.contributor.authorKeogh, JB
dc.contributor.authorMeikle, PJ
dc.contributor.authorClifton, PM
dc.date.accessioned2020-12-21T02:04:58Z
dc.date.available2020-12-21T02:04:58Z
dc.date.issued2017-08-01
dc.identifierpii: nu9080886
dc.identifier.citationTurner, K. M., Keogh, J. B., Meikle, P. J. & Clifton, P. M. (2017). Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. NUTRIENTS, 9 (8), https://doi.org/10.3390/nu9080886.
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11343/256777
dc.description.abstractThere is a body of evidence linking inflammation, altered lipid metabolism, and insulin resistance. Our previous research found that insulin sensitivity decreased after a four-week diet high in dairy compared to a control diet and to one high in red meat. Our aim was to determine whether a relationship exists between changes in insulin sensitivity and inflammatory biomarkers, or with lipid species. Fasting Tumor Necrosis Factor alpha (TNF-α), Tumor Necrosis Factor Receptor II (sTNF-RII), C-reactive protein (CRP), and lipids were measured at the end of each diet. TNF-α and the ratio TNF-α/sTNF-RII were not different between diets and TNF-α, sTNF-RII, or the ratio TNF-α/sTNF-RII showed no association with homeostasis model assessment-estimated insulin resistance (HOMA-IR). A number of phosphatidylethanolamine (PE) and phosphatidylinositol (PI) species differed between dairy and red meat and dairy and control diets, as did many phosphatidylcholine (PC) species and cholesteryl ester (CE) 14:0, CE15:0, lysophosphatidylcholine (LPC) 14:0, and LPC15:0. None had a significant relationship (p = 0.001 or better) with log homeostasis model assessment-estimated insulin resistance (HOMA-IR), although LPC14:0 had the strongest relationship (p = 0.004) and may be the main mediator of the effect of dairy on insulin sensitivity. LPC14:0 and the whole LPC class were correlated with CRP. The correlations between dietary change and the minor plasma phospholipids PI32:1 and PE32:1 are novel and may reflect significant changes in membrane composition. Inflammatory markers were not altered by changes in protein source while the correlation of LPC with CRP confirms a relationship between changes in lipid profile and inflammation.
dc.languageEnglish
dc.publisherMDPI AG
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleChanges in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks
dc.typeJournal Article
dc.identifier.doi10.3390/nu9080886
melbourne.affiliation.departmentBio21
melbourne.source.titleNutrients
melbourne.source.volume9
melbourne.source.issue8
dc.rights.licenseCC BY
melbourne.elementsid1231317
melbourne.contributor.authorMeikle, Peter
dc.identifier.eissn2072-6643
melbourne.accessrightsOpen Access


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