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dc.contributor.authorZhang, Q-H
dc.contributor.authorYuen, WS
dc.contributor.authorAdhikari, D
dc.contributor.authorFlegg, JA
dc.contributor.authorFitzHarris, G
dc.contributor.authorConti, M
dc.contributor.authorSicinski, P
dc.contributor.authorNabti, I
dc.contributor.authorMarangos, P
dc.contributor.authorCarroll, J
dc.date.accessioned2020-12-21T02:06:09Z
dc.date.available2020-12-21T02:06:09Z
dc.date.issued2017-10-01
dc.identifierpii: jcb.201607111
dc.identifier.citationZhang, Q. -H., Yuen, W. S., Adhikari, D., Flegg, J. A., FitzHarris, G., Conti, M., Sicinski, P., Nabti, I., Marangos, P. & Carroll, J. (2017). Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II. JOURNAL OF CELL BIOLOGY, 216 (10), pp.3133-3143. https://doi.org/10.1083/jcb.201607111.
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11343/256785
dc.description.abstractCyclin A2 is a crucial mitotic Cdk regulatory partner that coordinates entry into mitosis and is then destroyed in prometaphase within minutes of nuclear envelope breakdown. The role of cyclin A2 in female meiosis and its dynamics during the transition from meiosis I (MI) to meiosis II (MII) remain unclear. We found that cyclin A2 decreases in prometaphase I but recovers after the first meiotic division and persists, uniquely for metaphase, in MII-arrested oocytes. Conditional deletion of cyclin A2 from mouse oocytes has no discernible effect on MI but leads to disrupted MII spindles and increased merotelic attachments. On stimulation of exit from MII, there is a dramatic increase in lagging chromosomes and an inhibition of cytokinesis. These defects are associated with an increase in microtubule stability in MII spindles, suggesting that cyclin A2 mediates the fidelity of MII by maintaining microtubule dynamics during the rapid formation of the MII spindle.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleCyclin A2 modulates kinetochore-microtubule attachment in meiosis II
dc.typeJournal Article
dc.identifier.doi10.1083/jcb.201607111
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.source.titleThe Journal of Cell Biology
melbourne.source.volume216
melbourne.source.issue10
melbourne.source.pages3133-3143
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1232055
melbourne.contributor.authorFlegg, Jennifer
dc.identifier.eissn1540-8140
melbourne.accessrightsOpen Access


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