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    Access and use of human tissues from the developing world: ethical challenges and a way forward using a tissue trust

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    Author
    Emerson, CI; Singer, PA; Upshur, REG
    Date
    2011-01-25
    Source Title
    BMC Medical Ethics
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Singer, Peter
    Affiliation
    School of Historical and Philosophical Studies
    Metadata
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    Document Type
    Journal Article
    Citations
    Emerson, C. I., Singer, P. A. & Upshur, R. E. G. (2011). Access and use of human tissues from the developing world: ethical challenges and a way forward using a tissue trust. BMC MEDICAL ETHICS, 12 (1), https://doi.org/10.1186/1472-6939-12-2.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256806
    DOI
    10.1186/1472-6939-12-2
    Abstract
    BACKGROUND: Scientists engaged in global health research are increasingly faced with barriers to access and use of human tissues from the developing world communities where much of their research is targeted. In part, the problem can be traced to distrust of researchers from affluent countries, given the history of 'scientific-imperialism' and 'biocolonialism' reflected in past well publicized cases of exploitation of research participants from low to middle income countries. DISCUSSION: To a considerable extent, the failure to adequately engage host communities, the opacity of informed consent, and the lack of fair benefit-sharing have played a significant role in eroding trust. These ethical considerations are central to biomedical research in low to middle income countries and failure to attend to them can inadvertently contribute to exploitation and erode trust. A 'tissue trust' may be a plausible means for enabling access to human tissues for research in a manner that is responsive to the ethical challenges considered. SUMMARY: Preventing exploitation and restoring trust while simultaneously promoting global health research calls for innovative approaches to human tissues research. A tissue trust can reduce the risk of exploitation and promote host capacity as a key benefit.

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