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dc.contributor.authorDi Biase, MA
dc.contributor.authorZalesky, A
dc.contributor.authorO'keefe, G
dc.contributor.authorLaskaris, L
dc.contributor.authorBaune, BT
dc.contributor.authorWeickert, CS
dc.contributor.authorOlver, J
dc.contributor.authorMcGorry, PD
dc.contributor.authorAmminger, GP
dc.contributor.authorNelson, B
dc.contributor.authorScott, AM
dc.contributor.authorHickie, I
dc.contributor.authorBanati, R
dc.contributor.authorTurkheimer, F
dc.contributor.authorYaqub, M
dc.contributor.authorEverall, IP
dc.contributor.authorPantelis, C
dc.contributor.authorCropley, V
dc.date.accessioned2020-12-21T02:13:47Z
dc.date.available2020-12-21T02:13:47Z
dc.date.issued2017-08-29
dc.identifierpii: tp2017193
dc.identifier.citationDi Biase, M. A., Zalesky, A., O'keefe, G., Laskaris, L., Baune, B. T., Weickert, C. S., Olver, J., McGorry, P. D., Amminger, G. P., Nelson, B., Scott, A. M., Hickie, I., Banati, R., Turkheimer, F., Yaqub, M., Everall, I. P., Pantelis, C. & Cropley, V. (2017). PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia. TRANSLATIONAL PSYCHIATRY, 7 (8), https://doi.org/10.1038/tp.2017.193.
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/11343/256836
dc.description.abstractWe examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified using [11C](R)-(1-[2-chrorophynyl]-N-methyl-N-[1-methylpropyl]-3 isoquinoline carboxamide (11C-(R)-PK11195) positron emission tomography (PET) in: (i) 10 individuals at ultra-high risk (UHR) of psychosis; (ii) 18 patients recently diagnosed with schizophrenia; (iii) 15 patients chronically ill with schizophrenia; and, (iv) 27 age-matched healthy controls. Regional-binding potential (BPND) was calculated using the simplified reference-tissue model with four alternative reference inputs. The UHR, recent-onset and chronic patient groups were compared to age-matched healthy control groups to examine between-group BPND differences in 6 regions: dorsal frontal, orbital frontal, anterior cingulate, medial temporal, thalamus and insula. Correlation analysis tested for BPND associations with gray matter volume, peripheral cytokines and clinical variables. The null hypothesis of equality in BPND between patients (UHR, recent-onset and chronic) and respective healthy control groups (younger and older) was not rejected for any group comparison or region. Across all subjects, BPND was positively correlated to age in the thalamus (r=0.43, P=0.008, false discovery rate). No correlations with regional gray matter, peripheral cytokine levels or clinical symptoms were detected. We therefore found no evidence of microglial activation in groups of individuals at high risk, recently diagnosed or chronically ill with schizophrenia. While the possibility of 11C-(R)-PK11195-binding differences in certain patient subgroups remains, the patient cohorts in our study, who also displayed normal peripheral cytokine profiles, do not substantiate the assumption of microglial activation in schizophrenia as a regular and defining feature, as measured by 11C-(R)-PK11195 BPND.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titlePET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
dc.typeJournal Article
dc.identifier.doi10.1038/tp.2017.193
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleTranslational Psychiatry
melbourne.source.volume7
melbourne.source.issue8
melbourne.identifier.nhmrc1065742
melbourne.identifier.nhmrc628880
melbourne.identifier.nhmrc628386
melbourne.identifier.nhmrc1105825
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1232972
melbourne.contributor.authorPantelis, Christos
melbourne.contributor.authorZalesky, Andrew
melbourne.contributor.authorShannon Weickert, Cynthia
melbourne.contributor.authorOlver, James
melbourne.contributor.authorMcGorry, Patrick
melbourne.contributor.authorAmminger, Guenter
melbourne.contributor.authorEverall, Ian
melbourne.contributor.authorCropley, Vanessa
melbourne.contributor.authorScott, Andrew
melbourne.contributor.authorNelson, Christopher
melbourne.contributor.authorDi Biase, Maria
melbourne.contributor.authorO'Keefe, Graeme
melbourne.contributor.authorBaune, Bernhard
melbourne.contributor.authorLaskaris, Liliana
dc.identifier.eissn2158-3188
melbourne.identifier.fundernameidNHMRC, 1065742
melbourne.identifier.fundernameidNHMRC, 628880
melbourne.identifier.fundernameidNHMRC, 628386
melbourne.identifier.fundernameidNHMRC, 1105825
melbourne.accessrightsOpen Access


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