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dc.contributor.authorLeong, P
dc.contributor.authorLe Roux, P-Y
dc.contributor.authorCallahan, J
dc.contributor.authorSiva, S
dc.contributor.authorHofman, MS
dc.contributor.authorSteinfort, DP
dc.date.accessioned2020-12-21T02:15:10Z
dc.date.available2020-12-21T02:15:10Z
dc.date.issued2017-09-01
dc.identifierpii: RCR2253
dc.identifier.citationLeong, P., Le Roux, P. -Y., Callahan, J., Siva, S., Hofman, M. S. & Steinfort, D. P. (2017). Reduced ventilation-perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium-68 V/Q photon emission tomography/computed tomography. RESPIROLOGY CASE REPORTS, 5 (5), https://doi.org/10.1002/rcr2.253.
dc.identifier.issn2051-3380
dc.identifier.urihttp://hdl.handle.net/11343/256846
dc.description.abstractEndobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q-PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6-min walk distance (6MWD) without change in spirometry. Post-EBV V/Q-PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post-EBV V/Q-PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleReduced ventilation-perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium-68 V/Q photon emission tomography/computed tomography
dc.typeJournal Article
dc.identifier.doi10.1002/rcr2.253
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleRespirology Case Reports
melbourne.source.volume5
melbourne.source.issue5
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1234076
melbourne.contributor.authorSteinfort, Daniel
melbourne.contributor.authorSiva, Shankar
melbourne.contributor.authorHofman, Michael
dc.identifier.eissn2051-3380
melbourne.accessrightsOpen Access


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