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    Acute respiratory infections in hospitalized children in Vientiane, Lao PDR - the importance of Respiratory Syncytial Virus

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    Author
    Van, HN; Dubot-Peres, A; Russell, FM; Dance, DAB; Vilivong, K; Phommachan, S; Syladeth, C; Lai, J; Lim, R; Morpeth, M; ...
    Date
    2017-08-24
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Morpeth, Melinda; Russell, Fiona; Lim, Ruth
    Affiliation
    Paediatrics (RCH)
    Surgery (Austin & Northern Health)
    Metadata
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    Document Type
    Journal Article
    Citations
    Van, H. N., Dubot-Peres, A., Russell, F. M., Dance, D. A. B., Vilivong, K., Phommachan, S., Syladeth, C., Lai, J., Lim, R., Morpeth, M., Mayxay, M., Newton, P. N., Richet, H. & De lamballerie, X. (2017). Acute respiratory infections in hospitalized children in Vientiane, Lao PDR - the importance of Respiratory Syncytial Virus. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-09006-6.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256852
    DOI
    10.1038/s41598-017-09006-6
    Abstract
    The Human respiratory syncytial virus (RSV) is one of the most important viral pathogens, causing epidemics of acute respiratory infection (ARI), especially bronchiolitis and pneumonia, in children worldwide. To investigate the RSV burden in Laos, we conducted a one-year study in children <5 years old admitted to Mahosot Hospital, Vientiane Capital, to describe clinical and epidemiological characteristics and predictive factors for severity of RSV-associated ARI. Pooled nasal and throat swabs were tested using multiplex real-time PCR for 33 respiratory pathogens (FTD® kit). A total of 383 patients were included, 277 (72.3%) of whom presented with pneumonia. 377 (98.4%) patients were positive for at least one microorganism, of which RSV was the most common virus (41.0%), with a peak observed between June and September, corresponding to the rainy season. Most RSV inpatients had pneumonia (84.1%), of whom 35% had severe pneumonia. Children <3-months old were a high-risk group for severe pneumonia, independently of RSV infection. Our study suggests that RSV infection is frequent in Laos and commonly associated with pneumonia in hospitalized young children. Further investigations are required to provide a better overall view of the Lao nationwide epidemiology and public health burden of RSV infection over time.

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