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    Better Indigenous Risk stratification for Cardiac Health study (BIRCH) protocol: rationale and design of a cross-sectional and prospective cohort study to identify novel cardiovascular risk indicators in Aboriginal Australian and Torres Strait Islander adults

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    Author
    Remond, MGW; Stewart, S; Carrington, MJ; Marwick, TH; Kingwell, BA; Meikle, P; O'Brien, D; Marshall, NS; Maguire, GP
    Date
    2017-08-23
    Source Title
    BMC Cardiovascular Disorders
    Publisher
    BMC
    University of Melbourne Author/s
    Meikle, Peter; Kingwell, Bronwyn; Maguire, Graeme; Marwick, Thomas
    Affiliation
    Bio21
    Physiology
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Remond, M. G. W., Stewart, S., Carrington, M. J., Marwick, T. H., Kingwell, B. A., Meikle, P., O'Brien, D., Marshall, N. S. & Maguire, G. P. (2017). Better Indigenous Risk stratification for Cardiac Health study (BIRCH) protocol: rationale and design of a cross-sectional and prospective cohort study to identify novel cardiovascular risk indicators in Aboriginal Australian and Torres Strait Islander adults. BMC CARDIOVASCULAR DISORDERS, 17 (1), https://doi.org/10.1186/s12872-017-0662-7.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256871
    DOI
    10.1186/s12872-017-0662-7
    Abstract
    BACKGROUND: Of the estimated 10-11 year life expectancy gap between Indigenous (Aboriginal and Torres Strait Islander people) and non-Indigenous Australians, approximately one quarter is attributable to cardiovascular disease (CVD). Risk prediction of CVD is imperfect, but particularly limited for Indigenous Australians. The BIRCH (Better Indigenous Risk stratification for Cardiac Health) project aims to identify and assess existing and novel markers of early disease and risk in Indigenous Australians to optimise health outcomes in this disadvantaged population. It further aims to determine whether these markers are relevant in non-Indigenous Australians. METHODS/DESIGN: BIRCH is a cross-sectional and prospective cohort study of Indigenous and non-Indigenous Australian adults (≥ 18 years) living in remote, regional and urban locations. Participants will be assessed for CVD risk factors, left ventricular mass and strain via echocardiography, sleep disordered breathing and quality via home-based polysomnography or actigraphy respectively, and plasma lipidomic profiles via mass spectrometry. Outcome data will comprise CVD events and death over a period of five years. DISCUSSION: Results of BIRCH may increase understanding regarding the factors underlying the increased burden of CVD in Indigenous Australians in this setting. Further, it may identify novel markers of early disease and risk to inform the development of more accurate prediction equations. Better identification of at-risk individuals will promote more effective primary and secondary preventive initiatives to reduce Indigenous Australian health disadvantage.

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