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    A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression.

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    14
    Author
    Murphy, JA; Sarris, J; Byrne, GJ
    Date
    2017
    Source Title
    Depression Research and Treatment
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    Sarris, Jerome; Murphy, Jenifer
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Murphy, J. A., Sarris, J. & Byrne, G. J. (2017). A Review of the Conceptualisation and Risk Factors Associated with Treatment-Resistant Depression.. Depress Res Treat, 2017, pp.4176825-. https://doi.org/10.1155/2017/4176825.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256922
    DOI
    10.1155/2017/4176825
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559917
    Abstract
    Major depression does not always remit. Difficult-to-treat depression is thought to contribute to the large disease burden posed by depression. Treatment-resistant depression (TRD) is the conventional term for nonresponse to treatment in individuals with major depression. Indicators of the phenomenon are the poor response rates to antidepressants in clinical practice and the overestimation of the efficacy of antidepressants in medical scientific literature. Current TRD staging models are based on anecdotal evidence without an empirical rationale to rank one treatment strategy above another. Many factors have been associated with TRD such as inflammatory system activation, abnormal neural activity, neurotransmitter dysfunction, melancholic clinical features, bipolarity, and a higher traumatic load. This narrative review provides an overview of this complex clinical problem and discusses the reconceptualization of depression using an illness staging model in line with other medical fields such as oncology.

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