University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Florey Department of Neuroscience and Mental Health
  • Florey Department of Neuroscience and Mental Health - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry

    Thumbnail
    Download
    published version (914.3Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    14
    12
    Author
    Frost, S; Robinson, L; Rowe, CC; Ames, D; Masters, CL; Taddei, K; Rainey-Smith, SR; Martins, RN; Kanagasingam, Y
    Date
    2017-01-01
    Source Title
    Journal of Ophthalmology
    Publisher
    HINDAWI LTD
    University of Melbourne Author/s
    Ames, David; Rowe, Christopher; Masters, Colin
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Psychiatry
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Frost, S., Robinson, L., Rowe, C. C., Ames, D., Masters, C. L., Taddei, K., Rainey-Smith, S. R., Martins, R. N. & Kanagasingam, Y. (2017). Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry. JOURNAL OF OPHTHALMOLOGY, 2017, https://doi.org/10.1155/2017/7935406.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256930
    DOI
    10.1155/2017/7935406
    Abstract
    Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N = 14) and cognitively normal healthy control (HC, N = 115) participants, with the HC group stratified according to high (N = 38) and low (N = 77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p < 0.05, maximum velocity p < 0.0005, average velocity p < 0.005, and constriction amplitude p < 0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Psychiatry - Research Publications [1103]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1052]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors