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dc.contributor.authorFrost, S
dc.contributor.authorRobinson, L
dc.contributor.authorRowe, CC
dc.contributor.authorAmes, D
dc.contributor.authorMasters, CL
dc.contributor.authorTaddei, K
dc.contributor.authorRainey-Smith, SR
dc.contributor.authorMartins, RN
dc.contributor.authorKanagasingam, Y
dc.date.accessioned2020-12-21T02:26:51Z
dc.date.available2020-12-21T02:26:51Z
dc.date.issued2017-01-01
dc.identifier.citationFrost, S., Robinson, L., Rowe, C. C., Ames, D., Masters, C. L., Taddei, K., Rainey-Smith, S. R., Martins, R. N. & Kanagasingam, Y. (2017). Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry. JOURNAL OF OPHTHALMOLOGY, 2017, https://doi.org/10.1155/2017/7935406.
dc.identifier.issn2090-004X
dc.identifier.urihttp://hdl.handle.net/11343/256930
dc.description.abstractCortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N = 14) and cognitively normal healthy control (HC, N = 115) participants, with the HC group stratified according to high (N = 38) and low (N = 77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p < 0.05, maximum velocity p < 0.0005, average velocity p < 0.005, and constriction amplitude p < 0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEvaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry
dc.typeJournal Article
dc.identifier.doi10.1155/2017/7935406
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleJournal of Ophthalmology
melbourne.source.volume2017
dc.rights.licenseCC BY
melbourne.elementsid1233644
melbourne.contributor.authorAmes, David
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorMasters, Colin
dc.identifier.eissn2090-0058
melbourne.accessrightsOpen Access


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