University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+T cell response magnitude

    Thumbnail
    Download
    published version (950.1Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    4
    4
    Author
    Quinn, KM; Kan, W-T; Watson, KA; Liddicoat, BJ; Swan, NG; McQuilten, H; Denton, AE; Li, J; Chen, W; Brown, LE; ...
    Date
    2017-09-08
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    La Gruta, Nicole; Reading, Patrick; Doherty, Peter; Kedzierska, Katherine; KAN, WAN-TING; WATSON, KATHERINE; SWAN, NATASHA; McQuilten, Hayley; Brown, Lorena; Jackson, David; ...
    Affiliation
    Microbiology and Immunology
    Veterinary and Agricultural Sciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Quinn, K. M., Kan, W. -T., Watson, K. A., Liddicoat, B. J., Swan, N. G., McQuilten, H., Denton, A. E., Li, J., Chen, W., Brown, L. E., Jackson, D. C., Reading, P. C., Doherty, P. C., Kedzierska, K., Kedzierski, L., Turner, S. J. & La Gruta, N. L. (2017). Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+T cell response magnitude. PLOS ONE, 12 (9), https://doi.org/10.1371/journal.pone.0184732.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256933
    DOI
    10.1371/journal.pone.0184732
    Abstract
    TNF is a pro-inflammatory cytokine produced by both lymphoid and non-lymphoid cells. As a consequence of the widespread expression of its receptors (TNFR1 and 2), TNF plays a role in many important biological processes. In the context of influenza A virus (IAV) infection, TNF has variably been implicated in mediating immunopathology as well as suppression of the immune response. Although a number of cell types are able to produce TNF, the ability of CD8+ T cells to produce TNF following viral infection is a hallmark of their effector function. As such, the regulation and role of CD8+ T cell-derived TNF following viral infection is of great interest. Here, we show that the biphasic production of TNF by CD8+ T cells following in vitro stimulation corresponds to distinct patterns of epigenetic modifications. Further, we show that a global loss of TNF during IAV infection results in an augmentation of the peripheral virus-specific CD8+ T cell response. Subsequent adoptive transfer experiments demonstrated that this attenuation of the CD8+ T cell response was largely, but not exclusively, conferred by extrinsic TNF, with intrinsically-derived TNF making only modest contributions. In conclusion, TNF exerts an immunoregulatory role on CD8+ T cell responses following IAV infection, an effect that is largely mediated by extrinsically-derived TNF.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Veterinary and Agricultural Sciences Collected Works - Research Publications [300]
    • Microbiology & Immunology - Research Publications [1555]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors