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dc.contributor.authorHofmann, NE
dc.contributor.authorKari, S
dc.contributor.authorWampfler, R
dc.contributor.authorKiniboro, B
dc.contributor.authorTeliki, A
dc.contributor.authorIga, J
dc.contributor.authorWaltmann, A
dc.contributor.authorBetuela, I
dc.contributor.authorFelger, I
dc.contributor.authorRobinson, LJ
dc.contributor.authorMueller, I
dc.date.accessioned2020-12-21T02:28:33Z
dc.date.available2020-12-21T02:28:33Z
dc.date.issued2017-09-01
dc.identifierpii: 23708
dc.identifier.citationHofmann, N. E., Kari, S., Wampfler, R., Kiniboro, B., Teliki, A., Iga, J., Waltmann, A., Betuela, I., Felger, I., Robinson, L. J. & Mueller, I. (2017). The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea. ELIFE, 6, https://doi.org/10.7554/eLife.23708.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11343/256942
dc.description.abstractThe molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02143934.
dc.languageEnglish
dc.publisherELIFE SCIENCES PUBLICATIONS LTD
dc.titleThe complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea
dc.typeJournal Article
dc.identifier.doi10.7554/eLife.23708
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleeLife
melbourne.source.volume6
dc.rights.licenseCC BY
melbourne.elementsid1235360
melbourne.contributor.authorRobinson, Leanne
melbourne.contributor.authorMueller, Ivo
melbourne.contributor.authorKarl, Stephan
melbourne.contributor.authorWaltmann, Andreea
dc.identifier.eissn2050-084X
melbourne.accessrightsOpen Access


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