Show simple item record

dc.contributor.authorSaw, W-Y
dc.contributor.authorTantoso, E
dc.contributor.authorBegum, H
dc.contributor.authorZhou, L
dc.contributor.authorZou, R
dc.contributor.authorHe, C
dc.contributor.authorChan, SL
dc.contributor.authorTan, LW-L
dc.contributor.authorWong, L-P
dc.contributor.authorXu, W
dc.contributor.authorKyin, D
dc.contributor.authorMoong, N
dc.contributor.authorLim, Y
dc.contributor.authorLi, B
dc.contributor.authorPillai, NE
dc.contributor.authorPeterson, TA
dc.contributor.authorBielawny, T
dc.contributor.authorMeikle, PJ
dc.contributor.authorMundra, PA
dc.contributor.authorLim, W-Y
dc.contributor.authorLuo, M
dc.contributor.authorChia, K-S
dc.contributor.authorOng, RT-H
dc.contributor.authorBrunham, LR
dc.contributor.authorKhor, C-C
dc.contributor.authorToo, HP
dc.contributor.authorSoong, R
dc.contributor.authorWenk, MR
dc.contributor.authorLittle, P
dc.contributor.authorTeo, Y-Y
dc.date.accessioned2020-12-21T02:30:52Z
dc.date.available2020-12-21T02:30:52Z
dc.date.issued2017-09-21
dc.identifierpii: 10.1038/s41467-017-00413-x
dc.identifier.citationSaw, W. -Y., Tantoso, E., Begum, H., Zhou, L., Zou, R., He, C., Chan, S. L., Tan, L. W. -L., Wong, L. -P., Xu, W., Kyin, D., Moong, N., Lim, Y., Li, B., Pillai, N. E., Peterson, T. A., Bielawny, T., Meikle, P. J., Mundra, P. A. ,... Teo, Y. -Y. (2017). Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/s41467-017-00413-x.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/256957
dc.description.abstractThe Singapore Integrative Omics Study provides valuable insights on establishing population reference measurement in 364 Chinese, Malay, and Indian individuals. These measurements include > 2.5 millions genetic variants, 21,649 transcripts expression, 282 lipid species quantification, and 284 clinical, lifestyle, and dietary variables. This concept paper introduces the depth of the data resource, and investigates the extent of ethnic variation at these omics and non-omics biomarkers. It is evident that there are specific biomarkers in each of these platforms to differentiate between the ethnicities, and intra-population analyses suggest that Chinese and Indians are the most biologically homogeneous and heterogeneous, respectively, of the three groups. Consistent patterns of correlations between lipid species also suggest the possibility of lipid tagging to simplify future lipidomics assays. The Singapore Integrative Omics Study is expected to allow the characterization of intra-omic and inter-omic correlations within and across all three ethnic groups through a systems biology approach.The Singapore Genome Variation projects characterized the genetics of Singapore's Chinese, Malay, and Indian populations. The Singapore Integrative Omics Study introduced here goes further in providing multi-omic measurements in individuals from these populations, including genetic, transcriptome, lipidome, and lifestyle data, and will facilitate the study of common diseases in Asian communities.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleEstablishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-017-00413-x
melbourne.affiliation.departmentBio21
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1236684
melbourne.contributor.authorMeikle, Peter
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record