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    Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat

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    Author
    Debebe, T; Holtze, S; Morhart, M; Hildebrandt, TB; Rodewald, S; Huse, K; Platzer, M; Wyohannes, D; Yirga, S; Lemma, A; ...
    Date
    2016-05-28
    Source Title
    Gut Pathogens
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Hildebrandt, Thomas
    Affiliation
    School of BioSciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Debebe, T., Holtze, S., Morhart, M., Hildebrandt, T. B., Rodewald, S., Huse, K., Platzer, M., Wyohannes, D., Yirga, S., Lemma, A., Thieme, R., Koenig, B. & Birkenmeier, G. (2016). Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat. GUT PATHOGENS, 8 (1), https://doi.org/10.1186/s13099-016-0107-3.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256966
    DOI
    10.1186/s13099-016-0107-3
    Abstract
    BACKGROUND: A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this reason the study of the gut microbiota of a mammal exhibiting an extraordinary life span is of great importance. The naked mole-rat (Heterocephalus glaber) is a eusocial mammal known for its longevity and cancer resistance. METHODS: Here we analyzed its gut microbiota by cultivating the bacteria under aerobic and anaerobic conditions and identifying their species by mass spectrometry. RESULTS: Altogether, 29 species of microbes were identified, predominantly belonging to Firmicutes, and Bacteroidetes. The most frequent species were Bacillus megaterium (45.2 %), followed by Bacteroides thetaiotaomicron (19.4 %), Bacteroides ovatus, Staphylococcus sciuri and Paenibacillus spp., each with a frequency of 16.1 %. CONCLUSION: Overall, the gut of the naked mole-rat is colonized by diverse, but low numbers of cultivable microbes compared with humans and mice. The primary food plants of the rodents are rich in polyphenols and related compounds, possessing anti-microbial, anti-inflammatory, anti-oxidative as well as anti-cancer activity which may contribute to their exceptionally healthy life.

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