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dc.contributor.authorDziegelewska, M
dc.contributor.authorHoltze, S
dc.contributor.authorVole, C
dc.contributor.authorWachter, U
dc.contributor.authorMenzel, U
dc.contributor.authorMorhart, M
dc.contributor.authorGroth, M
dc.contributor.authorSzafranski, K
dc.contributor.authorSahm, A
dc.contributor.authorSponholz, C
dc.contributor.authorDammannc, P
dc.contributor.authorHuse, K
dc.contributor.authorHildebrandt, T
dc.contributor.authorPlatzer, M
dc.date.accessioned2020-12-21T02:32:39Z
dc.date.available2020-12-21T02:32:39Z
dc.date.issued2016-08-01
dc.identifierpii: S2213-2317(16)30008-8
dc.identifier.citationDziegelewska, M., Holtze, S., Vole, C., Wachter, U., Menzel, U., Morhart, M., Groth, M., Szafranski, K., Sahm, A., Sponholz, C., Dammannc, P., Huse, K., Hildebrandt, T. & Platzer, M. (2016). Low sulfide levels and a high degree of cystathionine p-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. REDOX BIOLOGY, 8, pp.192-198. https://doi.org/10.1016/j.redox.2016.01.008.
dc.identifier.issn2213-2317
dc.identifier.urihttp://hdl.handle.net/11343/256968
dc.description.abstractHydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood sulfide and maximum longevity residual. In addition, we show that the naked mole-rat cystathionine β-synthase (CBS), an enzyme whose activity in the liver significantly contributes to systemic sulfide levels, has lower activity in the liver and is activated to a higher degree by S-adenosylmethionine compared to other species. These results add complexity to the understanding of the role of H2S in aging and call for detailed research on naked mole-rat transsulfuration.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.titleLow sulfide levels and a high degree of cystathionine p-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat
dc.typeJournal Article
dc.identifier.doi10.1016/j.redox.2016.01.008
melbourne.affiliation.departmentSchool of BioSciences
melbourne.source.titleRedox Biology
melbourne.source.volume8
melbourne.source.pages192-198
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1237576
melbourne.contributor.authorHildebrandt, Thomas
dc.identifier.eissn2213-2317
melbourne.accessrightsOpen Access


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