University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Biology
  • Medical Biology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medical Biology
  • Medical Biology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

    Thumbnail
    Download
    published version (4.315Mb)

    Citations
    Scopus
    Web of Science
    Altmetric
    16
    15
    Author
    Longley, RJ; White, MT; Takashima, E; Morita, M; Kanoi, BN; Suen, CSNLW; Betuela, I; Kuehn, A; Sripoorote, P; Franca, CT; ...
    Date
    2017-09-01
    Source Title
    PLoS Neglected Tropical Diseases
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Robinson, Leanne; Mueller, Ivo; Longley, Rhea; Li Wai Suen, Connie; Tenorio Franca, Camila; Tenorio Franca, Camila
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Longley, R. J., White, M. T., Takashima, E., Morita, M., Kanoi, B. N., Suen, C. S. N. L. W., Betuela, I., Kuehn, A., Sripoorote, P., Franca, C. T., Siba, P., Robinson, L. J., Lacerda, M., Sattabongkot, J., Tsuboi, T. & Mueller, I. (2017). Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. PLOS NEGLECTED TROPICAL DISEASES, 11 (9), https://doi.org/10.1371/journal.pntd.0005888.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/256980
    DOI
    10.1371/journal.pntd.0005888
    Abstract
    Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Medical Biology - Research Publications [865]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors