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dc.contributor.authorLongley, RJ
dc.contributor.authorWhite, MT
dc.contributor.authorTakashima, E
dc.contributor.authorMorita, M
dc.contributor.authorKanoi, BN
dc.contributor.authorSuen, CSNLW
dc.contributor.authorBetuela, I
dc.contributor.authorKuehn, A
dc.contributor.authorSripoorote, P
dc.contributor.authorFranca, CT
dc.contributor.authorSiba, P
dc.contributor.authorRobinson, LJ
dc.contributor.authorLacerda, M
dc.contributor.authorSattabongkot, J
dc.contributor.authorTsuboi, T
dc.contributor.authorMueller, I
dc.date.accessioned2020-12-21T02:34:19Z
dc.date.available2020-12-21T02:34:19Z
dc.date.issued2017-09-01
dc.identifierpii: PNTD-D-17-00662
dc.identifier.citationLongley, R. J., White, M. T., Takashima, E., Morita, M., Kanoi, B. N., Suen, C. S. N. L. W., Betuela, I., Kuehn, A., Sripoorote, P., Franca, C. T., Siba, P., Robinson, L. J., Lacerda, M., Sattabongkot, J., Tsuboi, T. & Mueller, I. (2017). Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. PLOS NEGLECTED TROPICAL DISEASES, 11 (9), https://doi.org/10.1371/journal.pntd.0005888.
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/11343/256980
dc.description.abstractPlasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleNaturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pntd.0005888
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titlePLoS Neglected Tropical Diseases
melbourne.source.volume11
melbourne.source.issue9
dc.rights.licenseCC BY
melbourne.elementsid1235359
melbourne.contributor.authorRobinson, Leanne
melbourne.contributor.authorMueller, Ivo
melbourne.contributor.authorLongley, Rhea
melbourne.contributor.authorLi Wai Suen, Connie
melbourne.contributor.authorTenorio Franca, Camila
melbourne.contributor.authorTenorio Franca, Camila
dc.identifier.eissn1935-2735
melbourne.accessrightsOpen Access


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