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dc.contributor.authorDavies, J
dc.contributor.authorLi, SQ
dc.contributor.authorTong, SY
dc.contributor.authorBaird, RW
dc.contributor.authorBeaman, M
dc.contributor.authorHiggins, G
dc.contributor.authorCowie, BC
dc.contributor.authorCondon, JR
dc.contributor.authorDavis, JS
dc.date.accessioned2020-12-21T03:01:59Z
dc.date.available2020-12-21T03:01:59Z
dc.date.issued2017-09-08
dc.identifierpii: PONE-D-17-05416
dc.identifier.citationDavies, J., Li, S. Q., Tong, S. Y., Baird, R. W., Beaman, M., Higgins, G., Cowie, B. C., Condon, J. R. & Davis, J. S. (2017). Establishing contemporary trends in hepatitis B sero-epidemiology in an Indigenous population. PLOS ONE, 12 (9), https://doi.org/10.1371/journal.pone.0184082.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/257043
dc.description.abstractBACKGROUND: Indigenous populations globally are disproportionately affected by chronic hepatitis B virus (HBV) infection however contemporary sero-prevalence data are often absent. In the Indigenous population of the Northern Territory (NT) of Australia the unique C4 sub-genotype of HBV universally circulates. There are no studies of the sero-prevalence, nor the impact of the vaccination program (which has a serotype mismatch compared to C4), at a population-wide level. METHODS: We examined all available HBV serology results obtained from the three main laboratories serving NT residents between 1991 and 2011. Data were linked with a NT government database to determine Indigenous status and the most recent test results for each individual were extracted as a cross-sectional database including 88,112 unique individuals. The primary aim was to obtain a contemporary estimate of HBsAg positivity for the NT by Indigenous status. RESULTS: Based on all tests from 2007-2011 (35,633 individuals), hepatitis B surface antigen (HBsAg) positivity was 3·40% (95%CI 3·19-3·61), being higher in Indigenous (6·08%[5·65%-6·53%]) than non-Indigenous (1·56%[1·38%-1·76%]) Australians, p<0·0001. Birth cohort analysis showed HBsAg positivity fell over time for Indigenous people, with this decrease commencing prior to universal infant vaccination (which commenced in 1990), with an ongoing but slower rate of decline since 1990, (0·23% decrease per year versus 0·17%). CONCLUSIONS: HBsAg positivity is high in the NT, particularly in the Indigenous population. HBsAg positivity has fallen over time but a substantial part of this decrease is due to factors other than the universal vaccination program.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEstablishing contemporary trends in hepatitis B sero-epidemiology in an Indigenous population
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0184082
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume12
melbourne.source.issue9
dc.rights.licenseCC BY
melbourne.elementsid1236801
melbourne.contributor.authorTong, Steven
melbourne.contributor.authorCowie, Benjamin
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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