Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder: a 10-week open-label study
AuthorBousman, CA; Mueller, DJ; Ng, CH; Byron, K; Berk, M; Singh, AB
Source TitlePharmacogenetics and Genomics
PublisherLIPPINCOTT WILLIAMS & WILKINS
University of Melbourne Author/sBerk, Michael; Ng, Chee; BYRON, KEITH ANDREW; Bousman, Chad; SINGH, AJEET
Document TypeJournal Article
CitationsBousman, C. A., Mueller, D. J., Ng, C. H., Byron, K., Berk, M. & Singh, A. B. (2017). Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder: a 10-week open-label study. PHARMACOGENETICS AND GENOMICS, 27 (1), pp.1-6. https://doi.org/10.1097/FPC.0000000000000253.
Access StatusOpen Access
BACKGROUND: Pharmacogenetic-based dosing support tools have been developed to personalize antidepressant-prescribing practice. However, the clinical validity of these tools has not been adequately tested, particularly for specific antidepressants. OBJECTIVE: To examine the concordance between the actual dose and a polygene pharmacogenetic predicted dose of desvenlafaxine needed to achieve symptom remission. MATERIALS AND METHODS: A 10-week, open-label, prospective trial of desvenlafaxine among Caucasian adults with major depressive disorder (n=119) was conducted. Dose was clinically adjusted and at the completion of the trial, the clinical dose needed to achieve remission was compared with the predicted dose needed to achieve remission. RESULTS: Among remitters (n=95), there was a strong concordance (Kendall's τ-b=0.84, P=0.0001; Cohen's κ=0.82, P=0.0001) between the actual and the predicted dose need to achieve symptom remission, showing high sensitivity (≥85%), specificity (≥86%), and accuracy (≥89%) of the tool. CONCLUSION: Findings provide initial evidence for the clinical validity of a polygene pharmacogenetic-based tool for desvenlafaxine dosing.
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