A fundamental bimodal role for neuropeptide Y1 receptor in the immune system
Web of Science
AuthorWheway, J; Mackay, CR; Newton, RA; Sainsbury, A; Boey, D; Herzog, H; Mackay, F
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sMackay, Fabienne
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsWheway, J., Mackay, C. R., Newton, R. A., Sainsbury, A., Boey, D., Herzog, H. & Mackay, F. (2005). A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. JOURNAL OF EXPERIMENTAL MEDICINE, 202 (11), pp.1527-1538. https://doi.org/10.1084/jem.20051971.
Access StatusOpen Access
Psychological conditions, including stress, compromise immune defenses. Although this concept is not novel, the molecular mechanism behind it remains unclear. Neuropeptide Y (NPY) in the central nervous system is a major regulator of numerous physiological functions, including stress. Postganglionic sympathetic nerves innervating lymphoid organs release NPY, which together with other peptides activate five Y receptors (Y1, Y2, Y4, Y5, and y(6)). Using Y1-deficient (Y1(-/-)) mice, we showed that Y1(-/-) T cells are hyperresponsive to activation and trigger severe colitis after transfer into lymphopenic mice. Thus, signaling through Y1 receptor on T cells inhibits T cell activation and controls the magnitude of T cell responses. Paradoxically, Y1(-/-) mice were resistant to T helper type 1 (Th1) cell-mediated inflammatory responses and showed reduced levels of the Th1 cell-promoting cytokine interleukin 12 and reduced interferon gamma production. This defect was due to functionally impaired antigen-presenting cells (APCs), and consequently, Y1(-/-) mice had reduced numbers of effector T cells. These results demonstrate a fundamental bimodal role for the Y1 receptor in the immune system, serving as a strong negative regulator on T cells as well as a key activator of APC function. Our findings uncover a sophisticated molecular mechanism regulating immune cell functions that can lead to stress-induced immunosuppression.
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