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dc.contributor.authorBoule, MW
dc.contributor.authorBroughton, C
dc.contributor.authorMackay, F
dc.contributor.authorAkira, S
dc.contributor.authorMarshak-Rothstein, A
dc.contributor.authorRifkin, IR
dc.date.accessioned2020-12-21T03:05:59Z
dc.date.available2020-12-21T03:05:59Z
dc.date.issued2004-06-21
dc.identifierpii: jem.20031942
dc.identifier.citationBoule, M. W., Broughton, C., Mackay, F., Akira, S., Marshak-Rothstein, A. & Rifkin, I. R. (2004). Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. JOURNAL OF EXPERIMENTAL MEDICINE, 199 (12), pp.1631-1640. https://doi.org/10.1084/jem.20031942.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257071
dc.description.abstractDendritic cell (DC) activation by nucleic acid-containing immunoglobulin (Ig)G complexes has been implicated in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms responsible for activation and subsequent disease induction are not completely understood. Here we show that murine DCs are much more effectively activated by immune complexes that contain IgG bound to chromatin than by immune complexes that contain foreign protein. Activation by these chromatin immune complexes occurs by two distinct pathways. One pathway involves dual engagement of the Fc receptor FcgammaRIII and Toll-like receptor (TLR)9, whereas the other is TLR9 independent. Furthermore, there is a characteristic cytokine profile elicited by the chromatin immune complexes that distinguishes this response from that of conventional TLR ligands, notably the induction of BAFF and the lack of induction of interleukin 12. The data establish a critical role for self-antigen in DC activation and explain how the innate immune system might drive the adaptive immune response in SLE.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleToll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20031942
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume199
melbourne.source.issue12
melbourne.source.pages1631-1640
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1115226
melbourne.contributor.authorMackay, Fabienne
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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