BAFF mediates survival of peripheral immature B lymphocytes
AuthorBatten, M; Groom, J; Cachero, TG; Qian, F; Schneider, P; Tschopp, J; Browning, JL; Mackay, F
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
AffiliationMedical Biology (W.E.H.I.)
Microbiology and Immunology
Document TypeJournal Article
CitationsBatten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L. & Mackay, F. (2000). BAFF mediates survival of peripheral immature B lymphocytes. JOURNAL OF EXPERIMENTAL MEDICINE, 192 (10), pp.1453-1465. https://doi.org/10.1084/jem.192.10.1453.
Access StatusOpen Access
B cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated proliferation. A role for BAFF in B cell survival was suggested by the observation of reduced peripheral B cell numbers in mice treated with reagents blocking BAFF, and high Bcl-2 levels detected in B cells from BAFF transgenic (Tg) mice. We tested in vitro the survival effect of BAFF on lymphocytes derived from primary and secondary lymphoid organs. BAFF induced survival of a subset of splenic immature B cells, referred to as transitional type 2 (T2) B cells. BAFF treatment allowed T2 B cells to survive and differentiate into mature B cells in response to signals through the BCR. The T2 and the marginal zone (MZ) B cell compartments were particularly enlarged in BAFF Tg mice. Immature transitional B cells are targets for negative selection, a feature thought to promote self-tolerance. These findings support a model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment. This work provides new clues on mechanisms regulating B cell maturation and tolerance.
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