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dc.contributor.authorBatten, M
dc.contributor.authorGroom, J
dc.contributor.authorCachero, TG
dc.contributor.authorQian, F
dc.contributor.authorSchneider, P
dc.contributor.authorTschopp, J
dc.contributor.authorBrowning, JL
dc.contributor.authorMackay, F
dc.date.accessioned2020-12-21T03:06:25Z
dc.date.available2020-12-21T03:06:25Z
dc.date.issued2000-11-20
dc.identifier.citationBatten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L. & Mackay, F. (2000). BAFF mediates survival of peripheral immature B lymphocytes. JOURNAL OF EXPERIMENTAL MEDICINE, 192 (10), pp.1453-1465. https://doi.org/10.1084/jem.192.10.1453.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257074
dc.description.abstractB cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated proliferation. A role for BAFF in B cell survival was suggested by the observation of reduced peripheral B cell numbers in mice treated with reagents blocking BAFF, and high Bcl-2 levels detected in B cells from BAFF transgenic (Tg) mice. We tested in vitro the survival effect of BAFF on lymphocytes derived from primary and secondary lymphoid organs. BAFF induced survival of a subset of splenic immature B cells, referred to as transitional type 2 (T2) B cells. BAFF treatment allowed T2 B cells to survive and differentiate into mature B cells in response to signals through the BCR. The T2 and the marginal zone (MZ) B cell compartments were particularly enlarged in BAFF Tg mice. Immature transitional B cells are targets for negative selection, a feature thought to promote self-tolerance. These findings support a model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment. This work provides new clues on mechanisms regulating B cell maturation and tolerance.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleBAFF mediates survival of peripheral immature B lymphocytes
dc.typeJournal Article
dc.identifier.doi10.1084/jem.192.10.1453
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume192
melbourne.source.issue10
melbourne.source.pages1453-1465
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1115235
melbourne.contributor.authorMackay, Fabienne
melbourne.contributor.authorGroom, Joanna
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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