BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
AuthorSchneider, P; MacKay, F; Steiner, V; Hofmann, K; Bodmer, JL; Holler, N; Ambrose, C; Lawton, P; Bixler, S; Acha-Orbea, H; ...
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sMackay, Fabienne
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsSchneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, J. L., Holler, N., Ambrose, C., Lawton, P., Bixler, S., Acha-Orbea, H., Valmori, D., Romero, P., Werner-Favre, C., Zubler, R. H., Browning, J. L. & Tschopp, J. (1999). BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. JOURNAL OF EXPERIMENTAL MEDICINE, 189 (11), pp.1747-1756. https://doi.org/10.1084/jem.189.11.1747.
Access StatusOpen Access
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
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