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dc.contributor.authorSchneider, P
dc.contributor.authorMacKay, F
dc.contributor.authorSteiner, V
dc.contributor.authorHofmann, K
dc.contributor.authorBodmer, JL
dc.contributor.authorHoller, N
dc.contributor.authorAmbrose, C
dc.contributor.authorLawton, P
dc.contributor.authorBixler, S
dc.contributor.authorAcha-Orbea, H
dc.contributor.authorValmori, D
dc.contributor.authorRomero, P
dc.contributor.authorWerner-Favre, C
dc.contributor.authorZubler, RH
dc.contributor.authorBrowning, JL
dc.contributor.authorTschopp, J
dc.date.accessioned2020-12-21T03:06:34Z
dc.date.available2020-12-21T03:06:34Z
dc.date.issued1999-06-07
dc.identifier.citationSchneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, J. L., Holler, N., Ambrose, C., Lawton, P., Bixler, S., Acha-Orbea, H., Valmori, D., Romero, P., Werner-Favre, C., Zubler, R. H., Browning, J. L. & Tschopp, J. (1999). BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. JOURNAL OF EXPERIMENTAL MEDICINE, 189 (11), pp.1747-1756. https://doi.org/10.1084/jem.189.11.1747.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257075
dc.description.abstractMembers of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleBAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
dc.typeJournal Article
dc.identifier.doi10.1084/jem.189.11.1747
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume189
melbourne.source.issue11
melbourne.source.pages1747-1756
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1115247
melbourne.contributor.authorMackay, Fabienne
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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