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    INDUCTION OF NEONATAL TOLERANCE TO H-2K IN B6 MICE DOES NOT ALLOW THE EMERGENCE OF T-CELLS SPECIFIC FOR H-2K PLUS VACCINIA VIRUS

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    Author
    SCHWARTZ, DH; DOHERTY, PC
    Date
    1982-01-01
    Source Title
    Journal of Experimental Medicine
    Publisher
    ROCKEFELLER UNIV PRESS
    University of Melbourne Author/s
    Doherty, Peter
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    SCHWARTZ, D. H. & DOHERTY, P. C. (1982). INDUCTION OF NEONATAL TOLERANCE TO H-2K IN B6 MICE DOES NOT ALLOW THE EMERGENCE OF T-CELLS SPECIFIC FOR H-2K PLUS VACCINIA VIRUS. JOURNAL OF EXPERIMENTAL MEDICINE, 156 (3), pp.810-821. https://doi.org/10.1084/jem.156.3.810.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257077
    DOI
    10.1084/jem.156.3.810
    Abstract
    Thymocytes and spleen cells from C57BL/6 mice (H-2b) neonatally tolerized to H-2k alloantigens do not generate an anti-vaccinia response restricted to H-2Kk when adoptively transferred to appropriate irradiated hosts. This is in sharp contrast to the case for negatively selected C57BL/6 spleen cells acutely depleted of alloreactivity. No evidence for suppression was found in cell mixture experiments. We have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 We now suggest that in the neonatally tolerized mouse, chronic, central delection of anti-H-2k clones during early T cell ontogeny eliminates the major source of cells able to give rise, via somatic mutation and expansion, to anti-H-2Kk + vaccinia specific cytotoxic T lymphocyte precursors (CTL-P) in the adult. A similar mechanism may operate in the (k + b) leads to b chimera; however, the presence of H-2kxb accessory and presenting cells may permit the eventual generation (via cross-stimulation) of an H-2k-restricted vaccinia-specific repertoire. This would account for our observation of such "aberrant recognition" CTL-P emerging in the spleens of older (k x b) leads to b chimeras.

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