INDUCTION OF NEONATAL TOLERANCE TO H-2K IN B6 MICE DOES NOT ALLOW THE EMERGENCE OF T-CELLS SPECIFIC FOR H-2K PLUS VACCINIA VIRUS
AuthorSCHWARTZ, DH; DOHERTY, PC
Source TitleJournal of Experimental Medicine
PublisherROCKEFELLER UNIV PRESS
University of Melbourne Author/sDoherty, Peter
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsSCHWARTZ, D. H. & DOHERTY, P. C. (1982). INDUCTION OF NEONATAL TOLERANCE TO H-2K IN B6 MICE DOES NOT ALLOW THE EMERGENCE OF T-CELLS SPECIFIC FOR H-2K PLUS VACCINIA VIRUS. JOURNAL OF EXPERIMENTAL MEDICINE, 156 (3), pp.810-821. https://doi.org/10.1084/jem.156.3.810.
Access StatusOpen Access
Thymocytes and spleen cells from C57BL/6 mice (H-2b) neonatally tolerized to H-2k alloantigens do not generate an anti-vaccinia response restricted to H-2Kk when adoptively transferred to appropriate irradiated hosts. This is in sharp contrast to the case for negatively selected C57BL/6 spleen cells acutely depleted of alloreactivity. No evidence for suppression was found in cell mixture experiments. We have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 We now suggest that in the neonatally tolerized mouse, chronic, central delection of anti-H-2k clones during early T cell ontogeny eliminates the major source of cells able to give rise, via somatic mutation and expansion, to anti-H-2Kk + vaccinia specific cytotoxic T lymphocyte precursors (CTL-P) in the adult. A similar mechanism may operate in the (k + b) leads to b chimera; however, the presence of H-2kxb accessory and presenting cells may permit the eventual generation (via cross-stimulation) of an H-2k-restricted vaccinia-specific repertoire. This would account for our observation of such "aberrant recognition" CTL-P emerging in the spleens of older (k x b) leads to b chimeras.
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