Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

Download
Author
Qiu, J; Zhang, R; Li, J; Sang, Y; Tang, W; Gil, PR; Liu, HDate
2015-01-01Source Title
International Journal of NanomedicinePublisher
DOVE MEDICAL PRESS LTDUniversity of Melbourne Author/s
Li, JianhuaAffiliation
Chemical and Biomolecular EngineeringMetadata
Show full item recordDocument Type
Journal ArticleCitations
Qiu, J., Zhang, R., Li, J., Sang, Y., Tang, W., Gil, P. R. & Liu, H. (2015). Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems. INTERNATIONAL JOURNAL OF NANOMEDICINE, 10 (1), pp.6709-6724. https://doi.org/10.2147/IJN.S91864.Access Status
Open AccessAbstract
Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References