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    Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

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    Author
    Qiu, J; Zhang, R; Li, J; Sang, Y; Tang, W; Gil, PR; Liu, H
    Date
    2015-01-01
    Source Title
    International Journal of Nanomedicine
    Publisher
    DOVE MEDICAL PRESS LTD
    University of Melbourne Author/s
    Li, Jianhua
    Affiliation
    Chemical and Biomolecular Engineering
    Metadata
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    Document Type
    Journal Article
    Citations
    Qiu, J., Zhang, R., Li, J., Sang, Y., Tang, W., Gil, P. R. & Liu, H. (2015). Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems. INTERNATIONAL JOURNAL OF NANOMEDICINE, 10 (1), pp.6709-6724. https://doi.org/10.2147/IJN.S91864.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257099
    DOI
    10.2147/IJN.S91864
    Abstract
    Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.

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