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dc.contributor.authorQiu, J
dc.contributor.authorZhang, R
dc.contributor.authorLi, J
dc.contributor.authorSang, Y
dc.contributor.authorTang, W
dc.contributor.authorGil, PR
dc.contributor.authorLiu, H
dc.date.accessioned2020-12-21T03:10:09Z
dc.date.available2020-12-21T03:10:09Z
dc.date.issued2015-01-01
dc.identifierpii: ijn-10-6709
dc.identifier.citationQiu, J., Zhang, R., Li, J., Sang, Y., Tang, W., Gil, P. R. & Liu, H. (2015). Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems. INTERNATIONAL JOURNAL OF NANOMEDICINE, 10 (1), pp.6709-6724. https://doi.org/10.2147/IJN.S91864.
dc.identifier.issn1178-2013
dc.identifier.urihttp://hdl.handle.net/11343/257099
dc.description.abstractGraphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.
dc.languageEnglish
dc.publisherDOVE MEDICAL PRESS LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleFluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
dc.typeJournal Article
dc.identifier.doi10.2147/IJN.S91864
melbourne.affiliation.departmentChemical and Biomolecular Engineering
melbourne.source.titleInternational Journal of Nanomedicine
melbourne.source.volume10
melbourne.source.issue1
melbourne.source.pages6709-6724
dc.rights.licenseCC BY-NC
melbourne.elementsid1238510
melbourne.contributor.authorLi, Jianhua
dc.identifier.eissn1178-2013
melbourne.accessrightsOpen Access


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