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dc.contributor.authorWillberg, CB
dc.contributor.authorMcConnell, JJ
dc.contributor.authorEriksson, EM
dc.contributor.authorBragg, LA
dc.contributor.authorYork, VA
dc.contributor.authorLiegler, TJ
dc.contributor.authorHecht, FM
dc.contributor.authorGrant, RM
dc.contributor.authorNixon, DF
dc.date.accessioned2020-12-21T03:13:54Z
dc.date.available2020-12-21T03:13:54Z
dc.date.issued2008-10
dc.identifier.citationWillberg, C. B., McConnell, J. J., Eriksson, E. M., Bragg, L. A., York, V. A., Liegler, T. J., Hecht, F. M., Grant, R. M. & Nixon, D. F. (2008). Immunity to HIV-1 is influenced by continued natural exposure to exogenous virus.. PLoS Pathog, 4 (10), pp.e1000185-. https://doi.org/10.1371/journal.ppat.1000185.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/257121
dc.description.abstractUnprotected sexual intercourse between individuals who are both infected with HIV-1 can lead to exposure to their partner's virus, and potentially to super-infection. However, the immunological consequences of continued exposure to HIV-1 by individuals already infected, has to our knowledge never been reported. We measured T cell responses in 49 HIV-1 infected individuals who were on antiretroviral therapy with suppressed viral loads. All the individuals were in a long-term sexual partnership with another HIV-1 infected individual, who was either also on HAART and suppressing their viral loads, or viremic (>9000 copies/ml). T cell responses to HIV-1 epitopes were measured directly ex-vivo by the IFN-gamma enzyme linked immuno-spot assay and by cytokine flow cytometry. Sexual exposure data was generated from questionnaires given to both individuals within each partnership. Individuals who continued to have regular sexual contact with a HIV-1 infected viremic partner had significantly higher frequencies of HIV-1-specific T cell responses, compared to individuals with aviremic partners. Strikingly, the magnitude of the HIV-1-specific T cell response correlated strongly with the level and route of exposure. Responses consisted of both CD4(+) and CD8(+) T cell subsets. Longitudinally, decreases in exposure were mirrored by a lower T cell response. However, no evidence for systemic super-infection was found in any of the individuals. Continued sexual exposure to exogenous HIV-1 was associated with increased HIV-1-specific T cell responses, in the absence of systemic super-infection, and correlated with the level and type of exposure.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleImmunity to HIV-1 is influenced by continued natural exposure to exogenous virus.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1000185
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titlePLoS Pathogens
melbourne.source.volume4
melbourne.source.issue10
melbourne.source.pagese1000185-
dc.rights.licenseCC BY
melbourne.elementsid1243010
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562513
melbourne.contributor.authorEriksson, Emily
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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