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dc.contributor.authorBenn, K
dc.contributor.authorSalman, S
dc.contributor.authorPage-Sharp, M
dc.contributor.authorDavis, TME
dc.contributor.authorButtery, JP
dc.date.accessioned2020-12-21T03:14:58Z
dc.date.available2020-12-21T03:14:58Z
dc.date.issued2017-08-11
dc.identifierpii: 905400
dc.identifier.citationBenn, K., Salman, S., Page-Sharp, M., Davis, T. M. E. & Buttery, J. P. (2017). Bradycardia and Hypothermia Complicating Azithromycin Treatment.. Am J Case Rep, 18, pp.883-886. https://doi.org/10.12659/ajcr.905400.
dc.identifier.issn1941-5923
dc.identifier.urihttp://hdl.handle.net/11343/257128
dc.description.abstractBACKGROUND Azithromycin is a macrolide antibiotic widely used to treat respiratory, urogenital, and other infections. Gastrointestinal upset, headache, and dizziness are common adverse effects, and prolongation of the rate-corrected electrocardiographic QT interval and malignant arrhythmias have been reported. There are rare reports of bradycardia and hypothermia but not in the same patient. CASE REPORT A 4-year-old boy given intravenous azithromycin as part of treatment for febrile neutropenia complicating leukemia chemotherapy developed hypothermia (rectal temperature 35.2°C) and bradycardia (65 beats/minute) after the second dose, which resolved over several days post-treatment, consistent with persistence of high tissue azithromycin concentrations relative to those in plasma. A sigmoid Emax pharmacokinetic/pharmacodynamic model suggested a maximal azithromycin-associated reduction in heart rate of 23 beats/minute. Monitoring for these potential adverse effects should facilitate appropriate supportive care in similar cases. CONCLUSIONS Recommended azithromycin doses can cause at least moderate bradycardia and hypothermia in vulnerable pediatric patients, adverse effects that should prompt appropriate monitoring and which may take many days to resolve.
dc.languageeng
dc.publisherInternational Scientific Information, Inc.
dc.titleBradycardia and Hypothermia Complicating Azithromycin Treatment.
dc.typeJournal Article
dc.identifier.doi10.12659/ajcr.905400
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleThe American journal of case reports
melbourne.source.volume18
melbourne.source.pages883-886
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1246222
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562267
melbourne.contributor.authorButtery, Jim
dc.identifier.eissn1941-5923
melbourne.accessrightsOpen Access


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