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    Improved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.

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    Author
    Anderson, N; Lawford, C; Khoo, V; Rolfo, M; Joon, DL; Wada, M
    Date
    2011-12
    Source Title
    Technology in Cancer Research and Treatment
    Publisher
    SAGE Publications
    University of Melbourne Author/s
    Wada, Mori
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Anderson, N., Lawford, C., Khoo, V., Rolfo, M., Joon, D. L. & Wada, M. (2011). Improved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.. Technol Cancer Res Treat, 10 (6), pp.575-583. https://doi.org/10.1177/153303461101000607.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257142
    DOI
    10.1177/153303461101000607
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509883
    Abstract
    Intensity-modulated radiotherapy (IMRT) has reduced the impact of acute and late toxicities associated with head and neck radiotherapy. Treatment planning system (TPS) advances in biological cost function based optimization (BBO) and improved segmentation techniques have increased organ at risk (OAR) sparing compared to conventional dose-based optimization (DBO). A planning study was undertaken to compare OAR avoidance in DBO and BBO treatment planning. Simultaneous integrated boost treatment plans were produced for 10 head and neck patients using both planning systems. Plans were compared for tar get coverage and OAR avoidance. Comparisons were made using the BBO TPS Monte Carlo dose engine to eliminate differences due to inherent algorithms. Target coverage (V95%) was maintained for both solutions. BBO produced lower OAR doses, with statistically significant improvement to left (12.3%, p = 0.005) and right parotid mean dose (16.9%, p = 0.004), larynx V50_Gy (71.0%, p = 0.005), spinal cord (21.9%, p < 0.001) and brain stem dose maximums (31.5%, p = 0.002). This study observed improved OAR avoidance with BBO planning. Further investigations will be undertaken to review any clinical benefit of this improved planned dosimetry.

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