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dc.contributor.authorAnderson, N
dc.contributor.authorLawford, C
dc.contributor.authorKhoo, V
dc.contributor.authorRolfo, M
dc.contributor.authorJoon, DL
dc.contributor.authorWada, M
dc.date.accessioned2020-12-21T03:17:16Z
dc.date.available2020-12-21T03:17:16Z
dc.date.issued2011-12
dc.identifierpii: c4318/Improved-Normal-Tissue-Sparing-in-Head-and-Neck-Radiotherapy-Using-Biological-Cost-Function-Based-IMRT-575-583-p17898.html
dc.identifier.citationAnderson, N., Lawford, C., Khoo, V., Rolfo, M., Joon, D. L. & Wada, M. (2011). Improved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.. Technol Cancer Res Treat, 10 (6), pp.575-583. https://doi.org/10.1177/153303461101000607.
dc.identifier.issn1533-0346
dc.identifier.urihttp://hdl.handle.net/11343/257142
dc.description.abstractIntensity-modulated radiotherapy (IMRT) has reduced the impact of acute and late toxicities associated with head and neck radiotherapy. Treatment planning system (TPS) advances in biological cost function based optimization (BBO) and improved segmentation techniques have increased organ at risk (OAR) sparing compared to conventional dose-based optimization (DBO). A planning study was undertaken to compare OAR avoidance in DBO and BBO treatment planning. Simultaneous integrated boost treatment plans were produced for 10 head and neck patients using both planning systems. Plans were compared for tar get coverage and OAR avoidance. Comparisons were made using the BBO TPS Monte Carlo dose engine to eliminate differences due to inherent algorithms. Target coverage (V95%) was maintained for both solutions. BBO produced lower OAR doses, with statistically significant improvement to left (12.3%, p = 0.005) and right parotid mean dose (16.9%, p = 0.004), larynx V50_Gy (71.0%, p = 0.005), spinal cord (21.9%, p < 0.001) and brain stem dose maximums (31.5%, p = 0.002). This study observed improved OAR avoidance with BBO planning. Further investigations will be undertaken to review any clinical benefit of this improved planned dosimetry.
dc.languageeng
dc.publisherSAGE Publications
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleImproved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.
dc.typeJournal Article
dc.identifier.doi10.1177/153303461101000607
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleTechnology in Cancer Research and Treatment
melbourne.source.volume10
melbourne.source.issue6
melbourne.source.pages575-583
dc.rights.licenseCC BY-NC
melbourne.elementsid1242787
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509883
melbourne.contributor.authorWada, Mori
dc.identifier.eissn1533-0338
melbourne.accessrightsOpen Access


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