University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (Austin & Northern Health)
  • Surgery (Austin & Northern Health) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (Austin & Northern Health)
  • Surgery (Austin & Northern Health) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Microvascular architecture of hepatic metastases in a mouse model.

    Thumbnail
    Download
    published version (1.224Mb)

    Citations
    Scopus
    Altmetric
    30
    Author
    Kuruppu, D; Christophi, C; O'Brien, PE
    Date
    1997
    Source Title
    HPB Surgery
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    Christophi, Christopher
    Affiliation
    Surgery (Austin & Northern Health)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Kuruppu, D., Christophi, C. & O'Brien, P. E. (1997). Microvascular architecture of hepatic metastases in a mouse model.. HPB Surg, 10 (3), pp.149-157. https://doi.org/10.1155/1997/52739.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257148
    DOI
    10.1155/1997/52739
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423855
    Abstract
    Development of effective treatment for hepatic metastases can be initiated by a better understanding of tumour vasculature and blood supply. This study was designed to characterise the microvascular architecture of hepatic metastases and observe the source of contributory blood supply from the host. Metastases were induced in mice by an intrasplenic injection of colon carcinoma cells (10(6) cells/ml.) Vascularization of tumours was studied over a three week period by scanning electron microscopy of microvascular corrosion casts. Metastatic liver involvement was observed initially within a week post induction, as areas approximately 100 microns in diameter not perfused by the casting resin. On histology these spaces corresponded to tumour cell aggregates. The following weeks highlighted the angiogenesis phase of these tumours as they received a vascular supply from adjacent hepatic sinusoids. Direct sinusoidal supply of metastases was maintained throughout tumour growth. At the tumour periphery most sinusoids were compressed to form a sheath demarcating the tumour from the hepatic vasculature. No direct supply from the hepatic artery or the portal vein was observed. Dilated vessels termed vascular lakes dominated the complex microvascular architecture of the tumours, most tapering as they traversed towards the periphery. Four vascular branching patterns could be identified as true loops, bifurcations and trifurcations, spirals and capillary networks. The most significant observation in this study was the direct sinusoidal supply of metastases, together with the vascular lakes and the peripheral sinusoidal sheaths of the tumour microculature.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Surgery (Austin & Northern Health) - Research Publications [277]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors