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dc.contributor.authorKuruppu, D
dc.contributor.authorChristophi, C
dc.contributor.authorO'Brien, PE
dc.date.accessioned2020-12-21T03:18:21Z
dc.date.available2020-12-21T03:18:21Z
dc.date.issued1997
dc.identifier.citationKuruppu, D., Christophi, C. & O'Brien, P. E. (1997). Microvascular architecture of hepatic metastases in a mouse model.. HPB Surg, 10 (3), pp.149-157. https://doi.org/10.1155/1997/52739.
dc.identifier.issn0894-8569
dc.identifier.urihttp://hdl.handle.net/11343/257148
dc.description.abstractDevelopment of effective treatment for hepatic metastases can be initiated by a better understanding of tumour vasculature and blood supply. This study was designed to characterise the microvascular architecture of hepatic metastases and observe the source of contributory blood supply from the host. Metastases were induced in mice by an intrasplenic injection of colon carcinoma cells (10(6) cells/ml.) Vascularization of tumours was studied over a three week period by scanning electron microscopy of microvascular corrosion casts. Metastatic liver involvement was observed initially within a week post induction, as areas approximately 100 microns in diameter not perfused by the casting resin. On histology these spaces corresponded to tumour cell aggregates. The following weeks highlighted the angiogenesis phase of these tumours as they received a vascular supply from adjacent hepatic sinusoids. Direct sinusoidal supply of metastases was maintained throughout tumour growth. At the tumour periphery most sinusoids were compressed to form a sheath demarcating the tumour from the hepatic vasculature. No direct supply from the hepatic artery or the portal vein was observed. Dilated vessels termed vascular lakes dominated the complex microvascular architecture of the tumours, most tapering as they traversed towards the periphery. Four vascular branching patterns could be identified as true loops, bifurcations and trifurcations, spirals and capillary networks. The most significant observation in this study was the direct sinusoidal supply of metastases, together with the vascular lakes and the peripheral sinusoidal sheaths of the tumour microculature.
dc.languageeng
dc.publisherHindawi Limited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMicrovascular architecture of hepatic metastases in a mouse model.
dc.typeJournal Article
dc.identifier.doi10.1155/1997/52739
melbourne.affiliation.departmentSurgery (Austin & Northern Health)
melbourne.source.titleHPB Surgery
melbourne.source.volume10
melbourne.source.issue3
melbourne.source.pages149-157
dc.rights.licenseCC BY
melbourne.elementsid1244088
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423855
melbourne.contributor.authorChristophi, Christopher
dc.identifier.eissn1607-8462
melbourne.accessrightsOpen Access


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