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    Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.

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    Author
    Diwakarla, C; Hannan, K; Hein, N; Yip, D
    Date
    2017-04-07
    Source Title
    World Journal of Gastroenterology
    Publisher
    Baishideng Publishing Group Inc.
    University of Melbourne Author/s
    Hannan, Katherine
    Affiliation
    Biochemistry and Molecular Biology
    Metadata
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    Document Type
    Journal Article
    Citations
    Diwakarla, C., Hannan, K., Hein, N. & Yip, D. (2017). Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.. World J Gastroenterol, 23 (13), pp.2276-2285. https://doi.org/10.3748/wjg.v23.i13.2276.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257152
    DOI
    10.3748/wjg.v23.i13.2276
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385394
    Abstract
    Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental improvements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel therapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.

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