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dc.contributor.authorKurts, C
dc.contributor.authorMiller, JFAP
dc.contributor.authorSubramaniam, RM
dc.contributor.authorCarbone, FR
dc.contributor.authorHeath, WR
dc.date.accessioned2020-12-21T03:19:42Z
dc.date.available2020-12-21T03:19:42Z
dc.date.issued1998-07-20
dc.identifier.citationKurts, C., Miller, J. F. A. P., Subramaniam, R. M., Carbone, F. R. & Heath, W. R. (1998). Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. JOURNAL OF EXPERIMENTAL MEDICINE, 188 (2), pp.409-414. https://doi.org/10.1084/jem.188.2.409.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/257157
dc.description.abstractNaive T cells recirculate mainly within the secondary lymphoid compartment, but once activated they can enter peripheral tissues and perform effector functions. To activate naive T cells, foreign antigens must traffic from the site of infection to the draining lymph nodes, where they can be presented by professional antigen presenting cells. For major histocompatibility complex class I-restricted presentation to CD8+ T cells, this can occur via the cross-presentation pathway. Here, we investigated the conditions allowing antigen access to this pathway. We show that the level of antigen expressed by peripheral tissues must be relatively high to facilitate cross-presentation to naive CD8+ T cells. Below this level, peripheral antigens did not stimulate by cross-presentation and were ignored by naive CD8+ T cells, although they could sensitize tissue cells for destruction by activated cytotoxic T lymphocytes (CTLs). Interestingly, CTL-mediated tissue destruction facilitated cross-presentation of low dose antigens for activation of naive CD8+ T cells. This represents the first in vivo evidence that cellular destruction can enhance access of exogenous antigens to the cross-presentation pathway. These data indicate that the cross-presentation pathway focuses on high dose antigens and those released during tissue destruction.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleMajor histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
dc.typeJournal Article
dc.identifier.doi10.1084/jem.188.2.409
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume188
melbourne.source.issue2
melbourne.source.pages409-414
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1116058
melbourne.contributor.authorHeath, William
melbourne.contributor.authorCarbone, Francis
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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