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    EXPRESSION OF 2 ALPHA-CHAINS ON THE SURFACE OF T-CELLS IN T-CELL RECEPTOR TRANSGENIC MICE

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    Author
    HEATH, WR; MILLER, J
    Date
    1993-11-01
    Source Title
    Journal of Experimental Medicine
    Publisher
    ROCKEFELLER UNIV PRESS
    University of Melbourne Author/s
    Heath, William
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    HEATH, W. R. & MILLER, J. (1993). EXPRESSION OF 2 ALPHA-CHAINS ON THE SURFACE OF T-CELLS IN T-CELL RECEPTOR TRANSGENIC MICE. JOURNAL OF EXPERIMENTAL MEDICINE, 178 (5), pp.1807-1811. https://doi.org/10.1084/jem.178.5.1807.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257159
    DOI
    10.1084/jem.178.5.1807
    Abstract
    CD8+ T cells taken directly from mice expressing a Kb-specific T cell receptor (TCR) transgene expressed the transgenic TCR in a bimodal profile as detected by flow cytometric analysis using a clonotype-specific monoclonal antibody. Those cells expressing the lower density of the transgenic TCR expressed the transgenic beta chain and two different alpha chains on their surface. One alpha chain was the product of the alpha transgene, whereas the other was derived by endogenous rearrangement. This report provides the first demonstration that T cells isolated directly from mice may express two different TCR clonotypes on their surface. The potential consequences of this finding for studies using TCR transgenic mice and for the induction of autoimmunity are discussed.

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