The evolving world of pseudoenzymes: proteins, prejudice and zombies

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    Author
    Eyers, PA; Murphy, JM
    Date
    2016-11-11
    Source Title
    BMC Biology
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Murphy, James
    Affiliation
    Medical Biology (W.E.H.I.)
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    Document Type
    Journal Article
    Citations
    Eyers, P. A. & Murphy, J. M. (2016). The evolving world of pseudoenzymes: proteins, prejudice and zombies. BMC BIOLOGY, 14 (1), https://doi.org/10.1186/s12915-016-0322-x.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257163
    DOI
    10.1186/s12915-016-0322-x
    Abstract
    Pseudoenzymes are catalytically deficient variants of enzymes that are represented in all major enzyme families. Their regulatory functions in signalling pathways are shedding new light on the non-catalytic functions of active enzymes, and are suggesting new ways to target cellular signalling mechanisms with drugs.

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