Seven newly identified loci for autoimmune thyroid disease.
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Date
2012-12-01Source Title
Human Molecular GeneticsPublisher
Oxford University Press (OUP)Affiliation
Obstetrics and GynaecologyMetadata
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Journal ArticleCitations
Cooper, J. D., Simmonds, M. J., Walker, N. M., Burren, O., Brand, O. J., Guo, H., Wallace, C., Stevens, H., Coleman, G., Wellcome Trust Case Control Consortium, Franklyn, J. A., Todd, J. A. & Gough, S. C. L. (2012). Seven newly identified loci for autoimmune thyroid disease.. Hum Mol Genet, 21 (23), pp.5202-5208. https://doi.org/10.1093/hmg/dds357.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518Abstract
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
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