Seven newly identified loci for autoimmune thyroid disease.

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    Author
    Cooper, JD; Simmonds, MJ; Walker, NM; Burren, O; Brand, OJ; Guo, H; Wallace, C; Stevens, H; Coleman, G; Wellcome Trust Case Control Consortium; ...
    Date
    2012-12-01
    Source Title
    Human Molecular Genetics
    Publisher
    Oxford University Press (OUP)
    University of Melbourne Author/s
    Scott, Clare
    Affiliation
    Obstetrics and Gynaecology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Cooper, J. D., Simmonds, M. J., Walker, N. M., Burren, O., Brand, O. J., Guo, H., Wallace, C., Stevens, H., Coleman, G., Wellcome Trust Case Control Consortium, Franklyn, J. A., Todd, J. A. & Gough, S. C. L. (2012). Seven newly identified loci for autoimmune thyroid disease.. Hum Mol Genet, 21 (23), pp.5202-5208. https://doi.org/10.1093/hmg/dds357.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257174
    DOI
    10.1093/hmg/dds357
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518
    Abstract
    Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

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