The role of hypoxia-induced miR-210 in cancer progression.
AuthorDang, K; Myers, KA
Source TitleInternational Journal of Molecular Sciences
University of Melbourne Author/sMyers, Kenneth
AffiliationMedicine (Austin & Northern Health)
Document TypeJournal Article
CitationsDang, K. & Myers, K. A. (2015). The role of hypoxia-induced miR-210 in cancer progression.. Int J Mol Sci, 16 (3), pp.6353-6372. https://doi.org/10.3390/ijms16036353.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394536
Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor development and growth by promoting the formation of a neoplastic environment. The recent discovery that a subset of cellular microRNAs (miRs) are upregulated during hypoxia, where they function to promote tumor development, highlights the importance of hypoxia-induced miRs as targets for continued investigation. miRs are short, non-coding transcripts involved in gene expression and regulation. Under hypoxic conditions, miR-210 becomes highly upregulated in response to hypoxia inducing factors (HIFs). HIF-1α drives miR-210's overexpression and the resultant alteration of cellular processes, including cell cycle regulation, mitochondria function, apoptosis, angiogenesis and metastasis. Here we discuss hypoxia-induced dysregulation of miR-210 and the resultant changes in miR-210 protein targets that regulate cancer progression. Potential methods of targeting miR-210 as a therapeutic tool are also explored.
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