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dc.contributor.authorMyers, KA
dc.contributor.authorBaas, PW
dc.date.accessioned2020-12-21T03:23:15Z
dc.date.available2020-12-21T03:23:15Z
dc.date.issued2007-09-10
dc.identifierpii: jcb.200702074
dc.identifier.citationMyers, K. A. & Baas, P. W. (2007). Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.. J Cell Biol, 178 (6), pp.1081-1091. https://doi.org/10.1083/jcb.200702074.
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11343/257183
dc.description.abstractKinesin-5 is a homotetrameric motor protein that interacts with adjacent microtubules in the mitotic spindle. Kinesin-5 is also highly expressed in developing postmitotic neurons. Axons of cultured neurons experimentally depleted of kinesin-5 grow up to five times longer than controls and display more branches. The faster growth rates are accompanied by a doubling of the frequency of transport of short microtubules, suggesting a major role for kinesin-5 in the balance of motor-driven forces on the axonal microtubule array. Live-cell imaging reveals that the effects on axonal length of kinesin-5 depletion are caused partly by a lower propensity of the axon and newly forming branches to undergo bouts of retraction. Overexpression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axonal length. These results indicate that kinesin-5 imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array.
dc.languageeng
dc.publisherRockefeller University Press
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleKinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.
dc.typeJournal Article
dc.identifier.doi10.1083/jcb.200702074
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleThe Journal of Cell Biology
melbourne.source.volume178
melbourne.source.issue6
melbourne.source.pages1081-1091
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1249370
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064629
melbourne.contributor.authorMyers, Kenneth
dc.identifier.eissn1540-8140
melbourne.accessrightsOpen Access


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