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    Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.

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    Author
    He, Y; Francis, F; Myers, KA; Yu, W; Black, MM; Baas, PW
    Date
    2005-02-28
    Source Title
    The Journal of Cell Biology
    Publisher
    Rockefeller University Press
    University of Melbourne Author/s
    Myers, Kenneth
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    He, Y., Francis, F., Myers, K. A., Yu, W., Black, M. M. & Baas, P. W. (2005). Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.. J Cell Biol, 168 (5), pp.697-703. https://doi.org/10.1083/jcb.200407191.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257184
    DOI
    10.1083/jcb.200407191
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171826
    Abstract
    Recent studies have shown that the transport of microtubules (MTs) and neurofilaments (NFs) within the axon is rapid, infrequent, asynchronous, and bidirectional. Here, we used RNA interference to investigate the role of cytoplasmic dynein in powering these transport events. To reveal transport of MTs and NFs, we expressed EGFP-tagged tubulin or NF proteins in cultured rat sympathetic neurons and performed live-cell imaging of the fluorescent cytoskeletal elements in photobleached regions of the axon. The occurrence of anterograde MT and retrograde NF movements was significantly diminished in neurons that had been depleted of dynein heavy chain, whereas the occurrence of retrograde MT and anterograde NF movements was unaffected. These results support a cargo model for NF transport and a sliding filament model for MT transport.

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