Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes
Web of Science
AuthorSeneviratne, U; Cook, MJ; D'Souza, WJ
Source TitleFrontiers in Neurology
PublisherFRONTIERS MEDIA SA
AffiliationMedicine and Radiology
Document TypeJournal Article
CitationsSeneviratne, U., Cook, M. J. & D'Souza, W. J. (2017). Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes. FRONTIERS IN NEUROLOGY, 8 (SEP), https://doi.org/10.3389/fneur2017.00499.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622315
Genetic generalized epilepsy (GGE) consists of several syndromes diagnosed and classified on the basis of clinical features and electroencephalographic (EEG) abnormalities. The main EEG feature of GGE is bilateral, synchronous, symmetric, and generalized spike-wave complex. Other classic EEG abnormalities are polyspikes, epileptiform K-complexes and sleep spindles, polyspike-wave discharges, occipital intermittent rhythmic delta activity, eye-closure sensitivity, fixation-off sensitivity, and photoparoxysmal response. However, admixed with typical changes, atypical epileptiform discharges are also commonly seen in GGE. There are circadian variations of generalized epileptiform discharges. Sleep, sleep deprivation, hyperventilation, intermittent photic stimulation, eye closure, and fixation-off are often used as activation techniques to increase the diagnostic yield of EEG recordings. Reflex seizure-related EEG abnormalities can be elicited by the use of triggers such as cognitive tasks and pattern stimulation during the EEG recording in selected patients. Distinct electrographic abnormalities to help classification can be identified among different electroclinical syndromes.
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