Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study
AuthorKuzma, E; Airdrie, J; Littlejohns, TJ; Lourida, I; Thompson-Coon, J; Lang, IA; Scrobotovici, M; Thacker, EL; Fitzpatrick, A; Kuller, LH; ...
Source TitleAlzheimer Disease and Associated Disorders
PublisherLIPPINCOTT WILLIAMS & WILKINS
University of Melbourne Author/sUkoumunne, Obioha
Document TypeJournal Article
CitationsKuzma, E., Airdrie, J., Littlejohns, T. J., Lourida, I., Thompson-Coon, J., Lang, I. A., Scrobotovici, M., Thacker, E. L., Fitzpatrick, A., Kuller, L. H., Lopez, O. L., Longstreth, W. T., Ukoumunne, O. C. & Llewellyn, D. J. (2017). Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 31 (2), pp.120-127. https://doi.org/10.1097/WAD.0000000000000191.
Access StatusOpen Access
INTRODUCTION: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. METHODS: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent dementia from the US population-based Cardiovascular Health Study (CHS) with adjudicated incident all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), and mixed dementia. RESULTS: In the CHS, the hazard ratio (HR) for all-cause dementia was 1.93 [95% confidence interval (CI), 1.36-2.74] for those with CABG history compared with those with no CABG history after adjustment for potential confounders. Similar HRs were observed for AD (HR=1.71; 95% CI, 0.98-2.98), VaD (HR=1.42; 95% CI, 0.56-3.65), and mixed dementia (HR=2.73; 95% CI, 1.55-4.80). The same pattern of results was observed when these CHS findings were pooled with a prior prospective study, the pooled HRs were 1.96 (95% CI, 1.42-2.69) for all-cause dementia, 1.71 (95% CI, 1.04-2.79) for AD and 2.20 (95% CI, 0.78-6.19) for VaD. DISCUSSION: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.
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