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    Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects

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    Author
    Giacomin, P; Zakrzewski, M; Croese, J; Su, X; Sotillo, J; McCann, L; Navarro, S; Mitreva, M; Krause, L; Loukas, A; ...
    Date
    2015-09-18
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Cantacessi, Cinzia
    Affiliation
    Veterinary Biosciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Giacomin, P., Zakrzewski, M., Croese, J., Su, X., Sotillo, J., McCann, L., Navarro, S., Mitreva, M., Krause, L., Loukas, A. & Cantacessi, C. (2015). Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. SCIENTIFIC REPORTS, 5 (1), https://doi.org/10.1038/srep13797.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257201
    DOI
    10.1038/srep13797
    Abstract
    The intestinal microbiota plays a critical role in the development of the immune system. Recent investigations have highlighted the potential of helminth therapy for treating a range of inflammatory disorders, including celiac disease (CeD); however, the mechanisms by which helminths modulate the immune response of the human host and ameliorate CeD pathology are unknown. In this study, we investigated the potential role of alterations in the human gut microbiota in helminth-mediated suppression of an inflammatory disease. We assessed the qualitative and quantitative changes in the microbiota of human volunteers with CeD prior to and following infection with human hookworms, and following challenge with escalating doses of dietary gluten. Experimental hookworm infection of the trial subjects resulted in maintenance of the composition of the intestinal flora, even after a moderate gluten challenge. Notably, we observed a significant increase in microbial species richness over the course of the trial, which could represent a potential mechanism by which hookworms can regulate gluten-induced inflammation and maintain intestinal immune homeostasis.

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