Arginine methylation of the B cell antigen receptor promotes differentiation.

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    Author
    Infantino, S; Benz, B; Waldmann, T; Jung, M; Schneider, R; Reth, M
    Date
    2010-04-12
    Source Title
    Journal of Experimental Medicine
    Publisher
    Rockefeller University Press
    University of Melbourne Author/s
    Infantino, Simona
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Infantino, S., Benz, B., Waldmann, T., Jung, M., Schneider, R. & Reth, M. (2010). Arginine methylation of the B cell antigen receptor promotes differentiation.. J Exp Med, 207 (4), pp.711-719. https://doi.org/10.1084/jem.20091303.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/257212
    DOI
    10.1084/jem.20091303
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856019
    Abstract
    Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.

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