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dc.contributor.authorOuladAbdelghani, M
dc.contributor.authorBouillet, P
dc.contributor.authorDecimo, D
dc.contributor.authorGansmuller, A
dc.contributor.authorHeyberger, S
dc.contributor.authorDolle, P
dc.contributor.authorBronner, S
dc.contributor.authorLutz, Y
dc.contributor.authorChambon, P
dc.date.accessioned2020-12-21T03:27:34Z
dc.date.available2020-12-21T03:27:34Z
dc.date.issued1996-10-01
dc.identifier.citationOuladAbdelghani, M., Bouillet, P., Decimo, D., Gansmuller, A., Heyberger, S., Dolle, P., Bronner, S., Lutz, Y. & Chambon, P. (1996). Characterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene. JOURNAL OF CELL BIOLOGY, 135 (2), pp.469-477. https://doi.org/10.1083/jcb.135.2.469.
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/11343/257213
dc.description.abstractThe full-length cDNA corresponding to Stra8, a novel gene inducible by retinoic acid (RA) in P19 embryonal carcinoma cells, has been isolated and shown to encode a 45-kD protein. Both Stra8 mRNA and protein were induced in cells treated by all-trans and 9-cis retinoic acids. Two-dimensional gel analysis and dephosphorylation experiments revealed that the two stereoisomers of RA differentially regulate the phosphorylation status of the Stra8 protein, which was shown to exist in differently phosphorylated forms. Subcellular fractionation and immunocytochemistry studies showed that the Stra8 protein is cytoplasmic. During mouse embryogenesis, Stra8 expression was restricted to the male developing gonads, and in adult mice, the expression of Stra8 was restricted to the premeiotic germ cells. Thus, Stra8 protein may play a role in the premeiotic phase of spermatogenesis.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleCharacterization of a premeiotic germ cell-specific cytoplasmic protein encoded by Stra8, a novel retinoic acid-responsive gene
dc.typeJournal Article
dc.identifier.doi10.1083/jcb.135.2.469
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleThe Journal of Cell Biology
melbourne.source.volume135
melbourne.source.issue2
melbourne.source.pages469-477
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1253046
melbourne.contributor.authorBouillet, Philippe
dc.identifier.eissn1540-8140
melbourne.accessrightsOpen Access


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